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Studies on athletes show whole-body cryotherapy reduces circulating levels of the pro-inflammatory cytokine IL-1 beta while increasing the anti-inflammatory cytokine IL-10 and the cytokine inhibitor IL-1 receptor antagonist (IL-1ra)

Growth hormone receptor upregulation amplifies regenerative signaling

Both share a molecular structure built around a cobalt ion coordinated within a corrin ring, a structure chemically similar to the heme group in hemoglobin