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Fatty acid/lipid metabolism in IR The specific insulin actions in adipose tissue include activation of glucose uptake and triglyceride synthesis, suppression of triglyceride hydrolysis and free fatty acids (FFA) and glycerol release into the blood circulation

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Activated caspase-3 further promotes Ca 2+ release, creating a vicious cycle that amplifies caspase-3 activation and ultimately results in oocyte apoptosis

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Combinatorial therapy of CDK9 inhibitor with CD19 CAR-T to reciprocally overcome therapy resistance and enhance treatment efficacies against aggressive B-Cell lymphomas

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