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Methods Culture conditions Three strains of anaerobic bacteria, isolated by culturomics studies 21,22,23 and obtained from the Collection de Souches de lUnit des Rickettsies (CSUR, Marseille, France), were used for this study: Clostridium sporogenes CSURP3957, Clostridium subterminale CSURP3759 and Romboutsia lituseburensis CSURP3909

Available medications can only minimise the symptoms but cannot cure the disease and this underlines the need to develop better therapeutic solutions for the disease