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Hidalgo A, Libby P, Soehnlein O, et al (2021) Neutrophil extracellular traps: from physiology to pathology

(c) nuclear translocation of predominantly p65/p50 dimers to induce transcription of target genes, including well-established FLICE-like inhibitory protein (c-FLIP) and apoptosis protein inhibitors (c-IAP)

Moreover, long-term clinical translation requires consideration of pharmacokinetics, pharmacodynamics, and combination indices to establish optimal drug ratios and dosing schedules

Circadian sleep wake-rhythm disorders evaluation The origin of a circadian rhythm disorder can be related either to an intrinsic abnormality in the circadian system itself (misalignment of the intrinsic circadian timing with the desired sleep schedule) or to external factors, as when individuals must be awake at times that are not synchronized with their intrinsic rhythms