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Long-Term Substitutions Patients seeking the antioxidant or anti-inflammatory benefits of GTE during isotretinoin therapy can consider: Dietary brewed green tea at 1 to 3 cups per day with meals (not supplements) Topical EGCG formulations, which bypass hepatic first-pass entirely and have shown benefit in acne management in the JID 2012 RCT [11] Reassessing GTE supplementation after isotretinoin completion and a minimum 4-week washout period Drug Interactions With Isotretinoin Beyond GTE: Context Matters GTE is not the only supplement concern during isotretinoin therapy

Nelson KB, Grether JK (1995) Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants

Front Cardiovasc Med 2020;7:580908

As with all medical procedures, potential patients should consult with a certified dermatology specialist to understand the risks, benefits, and costs associated with laser skin treatments