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Glutamate excitotoxicity can lead to increased production of neuronal nitrogen oxide synthase (nNOS) which in turn can lead to higher production of reactive nitrogen species, damage to cellular components, and ultimately, cell death (Sullivan and Brown, 2005), and this is thought to be mediated by the oxidative stress triggered by excitotoxicity (Nguyen et al., 2011)

Additional biomarkers like neuroinflammatory markers (e.g., TNF, IL6) and genetic variants (e.g., LRRK2, GBA mutations) contribute to early risk stratification [64, 79, 173, 250]

Em muitos casos, os estudos disponveis foram realizados apenas em animais ou em pesquisas preliminares, sem validao clnica robusta em seres humanos

As a key component in our anti-aging infusions, Biotin promotes collagen synthesis, contributing to firmer skin, stronger hair, and vibrant nails