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ANKIB1 is crucial for IRF3-activating, IFN-inducing TBK1 activation in primary murine immune cells upon activation of TLR3/4 and cGASSTING, but not RIG-I To understand the relevance of ANKIB1 in primary cells and in vivo, we generated Ankib1 / mice

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However, although preclinical animal studies have shown promising results, success in clinical trials has been limited, and the benefits of dietary antioxidant therapy in human NDs remain controversial