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This problem isnt small at all: As much as 25% of adults and up to 75% of children have needle-phobia

By analogy, protein (de)-phosphorylation, albeit thermodynamically favorable, is not controlled by the G for ATP hydrolysis or Atkinson's highly quoted energy charge (Atkinson and Fall, Examples of redox-regulated pathways Many cellular functions have been already associated with redox regulation

Moreover, the bioavailability and absorption of antioxidants vary between individuals, which complicates dosage recommendations

Intravenous routes are reserved for situations requiring rapid correction, whilst intramuscular administration is generally avoided in anticoagulated adults due to haematoma risk but is appropriate for neonatal prophylaxis