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10.1371/journal.pone.0037971 PLoS One 19 BindelsL.NeyrinckA.ClausS.Le RoyC.GrangetteC.PotB.et al (2016)

Abstract The phosphodiesterase-5 inhibitors (PDE5Is) are the first-line treatment option for men with erectile dysfunction (ED), with alprostadil considered a second-line choice