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In our study, PI3K, mTOR, Beclin-1 and LC3 II/I expression were elevated in the cerebral I/R group, along with increased levels of apoptotic makers, caspase-3, Bax, decrease of Bcl-2 content, as well as downregulation of intact neurons number in both cortex and hippocampal CA1 region

NQO1 supports sirtuin function and its role in transcription of target genes and sensing of mitochondrial stress

Comparison of the biochemical and pharmacologic properties of EDRF and NO provided initial evidence that NO is the major bioactive component of EDRF

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