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It is highly concentrated in the liver, where it helps identify and eliminate foreign compounds

Discovery and Nomenclature of GPX3 GPX3, also known as plasma glutathione peroxidase (GPX-P) or extracellular glutathione peroxidase (eGPX), is a unique member of the GPX family found extracellularly, notably in plasma [29]

The influence of GST polymorphisms on the increased risk of selected cancers occurrence Among the known isoenzymes of GST, the most studied polymorphisms in relation to cancers are the SNP in the GSTM1 , GSTT1 and GSTP1 genes [24]

Furthermore, sulfasalazine (SSA) and buthionine sulphoximine (BSO), which are inhibitors targeting NAC and GSH metabolism respectively, suppressed the tumor promoting effects induced by NAC and GSH in vitro and in vivo, and accompanied with significant increase in ROS level