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Several studies have demonstrated that knockout or inhibition of these three synthesizing enzymes can effectively suppress the occurrence and progression of ferroptosis [3032]

An in vivo study in mice using polyphenols extracted from Pueraria lobata root demonstrated an increase in the proliferation of beneficial microorganisms in the gut involving Lactobacillaceae and Bacteroidetes and simultaneous suppression of the abundance of Ruminococcaceae , Prevotellaceae , and Burkholderiaceae (Xu et al