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For instance, free fatty acids, such as palmitic acid, along with oxidation-specific epitopes, have the potential to activate TLR4 signaling pathways in PBMCs and adipocytes [161, 162]

136, # 32] Liu, Yuan

Synthetic chemistry methods All solvents and reagents were used as obtained from commercial sources unless otherwise indicated

Diagnosis Once the possibility of lipedema is considered, a good medical history will include an assessment of the food eaten, patterns of exercise, and a timeline of development of lipedema signs and symptoms with special attention to hormonal transitions in women including puberty, pregnancy, or menopause