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High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver

Although ideal production of melanin is associated with an effective defense against UV radiations, abnormal melanin biosynthesis and accumulation have been linked to several dermatological disorders in humans, such as hyperpigmentation and skin cancer

P.EykensC.RossaertE.HaeckW.et al

To find a more effective method for the cure and treatment of HCC, research for a better understanding of the mechanism involved in the development of cancer, OS-induced damage, and the effects of antioxidants is urgently required (Wang et al., 2016)