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Nat Rev Drug Discov 2:3851 Zambrowicz BP, Imamoto A, Fiering S, Herzenberg LA, Kerr WG, Soriano P (1997) Disruption of overlapping transcripts in the rosa beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells

Ello es especialmente relevante cuando se utiliza en exceso o si se consume sin que exista un dficit en dichas vitaminas, dado que en de existir en exceso las vitaminas pueden tener efectos nocivos