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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

Consequently, large-scale prospective studies involving patients with appropriate ALS diagnostic criteria to explicate the association between statin use and ALS are recommended in this regard

Cold Spring Harb Perspect Med 2(11): a012427 Samrot AV, Mohamed AA, Faradjeva E, Si Jie L, Hooi Sze C, Arif A, Sean TC, Michael EN, Mun CY, Qi NX, Mok PL, Kumar SS (2021) Mechanisms and impact of biofilms and targeting of biofilms using bioactive compoundsa review