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The American College of Obstetricians and Gynecologists (ACOG) and the American Diabetes Association (ADA) continue to recommend human insulin as the standard of care in pregnant women with diabetes mellitus and gestational diabetes mellitus (GDM) requiring medical therapy

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The inclusion and exclusion criteria were defined in direct accordance with the PICOS framework

As previously discussed, mutagenesis studies revealed that these residues are important for the NADase activity of human CD38, and changes in these residues led to the abolishment of the glycohydrolase activity and to an increase in the cyclase activity