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Over time, however, symptoms are likely to become more noticeable

Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation

10.1186/s13321-023-00737-5 197 ParkH.ZhouG.BaekM.BakerD.DiMaioF

Overall, these results point to a mechanism whereby baseline reductions in mitochondrial complex I activity in PD contribute to excessive inflammation through upregulation of inflammasome activity