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To note, aged rats with GH inhibition, which leads to reduced plasma IGF-1 levels, exhibit improved age-associated renal changes, including lower glomerulosclerosis, altered myofibroblast, reduced collagen content and less macrophage infiltration.64 Additionally, it has been observed that blocking IGF-1 signaling by inhibition of the IGF1R results in prevention of renal inflammation, tubular damage and fibrosis in a mouse model of diabetic kidney disease.65 These findings emerge the controversy regarding potential negative effects of IGF-1, suggesting that its role in kidney disease may not be entirely protective

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However, operators must carefully control ozone dosing to avoid the formation of byproducts like bromate

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