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As a fatty acid amide, PEA interacts with the peroxisome proliferator-activated receptor alpha (PPAR-$\alpha$) and G-protein coupled receptors to down-regulate mast cell activation, offering an advanced model for studying the mitigation of visceral pain and chronic neuro-inflammatory signaling along the enteric nervous system

As previously reviewed, a number of studies have investigated how AOM-induced weight loss affects bone density, and have indicated that rapid weight reduction may raise the risk of fractures by decreasing bone density, which a potentially serious side effect for obese patients with OA (111)

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utilized the antimicrobial peptide mCRAMP, a homolog of LL-37, to restore microbial equilibrium in IBD models (Fig