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The machine-learning algorithms are able to extract the biological information and detect DNA modifications (through identifying the differences in the electric current intensities generated by modified versus unmodified bases) [6], poly(A) tail length and RNA secondary structures [27], being in a constant state of development and optimization [13]

We systematically juxtapose two principal technology streams: (1) the display of protein antigens (through genetic, chemical, and bio-conjugation) and (2) the encapsulation of nucleic acid cargo (via physical, electrostatic, and programmable packaging mechanisms), evaluating each within this unified framework