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Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency

Berruti A, Generali D, Tampellini M

This study evidenced also that miR-503 levels were lower in osteosarcoma advanced stages compared with initial stages, and this could be helpful in the future to discriminate between different tumor stages also in clinical practice

Reportedly, glucose deprivation boosts up the reactive oxygen species and causes the death of cancer cells through inhibiting glycolysis and the pentose phosphate pathway [12], and lactic acid is known to promote NADPH production and maintains redox balance [13]