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In fact, evidence shows that many Type I and II tears respond well to conservative careparticularly when managed by an experienced physical therapist

Written consent was obtained from all patients or their relatives, and the study was approved by the Institutional Research Ethics Committee of the Institutes of Biomedical Sciences, Fudan University

In contrast, several studies suggested that the activation of ERK and JNK phosphorylates MITF at Ser 73 , which leads to its ubiquitination and degradation, thus subsequently down-regulating melanogenesis (not shown in Figure 3) [26,3941]