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This dimerization appears to induce a switch in intracellular signaling cascades in which administration of a dopamine agonist (quinpirole) alone leads to a rapid increase in Ca 2+ levels, an effect not observed in preparations expressing D2R in the absence of GHSR1a (Kern et al., 2012)

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While further studies are needed to substantiate these claims conclusively, the potential for MK-677 to promote a more youthful appearance is of interest to individuals seeking to combat signs of aging

Even so, the combination provides a well-characterized experimental framework for connecting pulsatile pituitary output to peripheral tissue remodeling responses