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Previous work suggested that only about 50% of all PD patients have a distribution of LBP in the brain that is entirely consistent with the Braak staging model, a prerequisite for the assumption that iLBD is a precursor for SNc pathology in PD [29, 214, 215], and about half of PD cases do not seem to show a caudo-rostral spread of LBP throughout the brain [216]

3.4 Evidence Base Neuropathy Trials : RCTs in diabetic neuropathy show 1,5003,000 mcg methylcobalamin daily improves nerve conduction velocities by up to 20% over 12 weeks

Biochemical treatment targets may be helpful (Table 10)

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