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AOD-9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone that specifically targets fat metabolism without systemic growth hormone effects

Furthermore, the relative abundance of Akkermansia , a genus positively associated with improvements in obesity-related metabolic issues 60 , was increased in the vehicle-treated group that underwent diet switch relative to the WD control group, suggesting a potential for distinct microbiome-mediated mechanisms of weight loss subsequent to diet switch from those of diet switch in combination with 5A-1MQ treatment

Acknowledgements We gratefully acknowledge the provision of human biomaterial (phBECs from control/non-chronic lung disease- and IPF-patients and FFPE sections of peritumoral tissue) and clinical data from the CPC-M bioArchive and its partners at the Asklepios Biobank Gauting, the LMU Hospital and the Ludwig-Maximilians-Universitt Mnchen