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[8] Documented risks Reported adverse events associated with high-dose or injectable glutathione used cosmetically include severe cutaneous reactions (including reports of StevensJohnson syndrome and toxic epidermal necrolysis), potential renal and thyroid dysfunction, abdominal pain, and the infection and embolism risks inherent to any unregulated injectable administered outside proper medical supervision

Given the significant changes in the liver after Cys restriction, we tested whether restoring Cse expression in a liver-specific manner can rescue the phenotype

Phosphorylation of eIF2 by PERK in response to ER stress decreases translation of mRNA and reduces stress (Harding et al , 2003)

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