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Therefore, there is a significant need to investigate the efficacy of complementary and alternative therapies and their tolerability in children with ASD while also identifying those that respond to these interventions

Takashi Tsuchiya (Department of Surgery, Sendai City Medical Center, Miyagi, Japan) for their cooperation in each collaboration and their critical comments and discussion during the preparation of this manuscript

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One widely held theory is that patients with a genetic predisposition and abnormal bacteria colonization, or dysbiosis, experience a gradual development of lymphocytes which are known as B cell clones which are susceptible to autoreactivity