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Genetic mutation of this gene can be seen in phenotypically hyperphagic, leptin-deficient, and obese ob/ob mice

These include: Oxidative stress: One of the more recent studies on DSIP, from 2011, concluded that the peptide has a strong antioxidant effect owing to an ability to activate the (rat) bodys natural mechanisms against oxidative stress.21 Edema (swelling via fluid buildup): Again in rats, a 1992 study suggested that DSIP may have an antiedematic effect related to the activation of the GABAergic system and inhibition of serotonin, noradrenaline, and histamine systems.22 Convulsions: Two rodent studies in the 1990s support DSIPs use as an anticonvulsant

Nerve and tissue repair: Research shows GHK-Cu promotes neurite outgrowth and supports repair of nerve tissue, making it a candidate peptide for post-surgical or neuropathy-adjacent protocols

Contraindication Signals from Compound-Level Research Active cancer or strong cancer history