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Proc Natl Acad Sci U S A 111(11):40014006

The latter has also shown to inhibit T2DM-associated mitochondrial deficiency and dysfunction in diabetic Goto-Kakizaki rats by suppressing enhanced autophagy in muscle cells (263, 264)

These compounds are renally eliminated and can accumulate in patients with renal dysfunction and may play a role in the development of thrombocytopenia Chronic liver failure History of vancomycin use Low baseline platelet level of less than 200 Low body weightLinezolid dosing does not change for adults nor require renal or hepatic impairment adjustment