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Leaf disc samples were cut from approximately five-week-old Arabidopsis rosettes with a leaf disc cork borer as described previously [23]

Also valine has been proven important for the oxidation of the reduced flavin by molecular oxygen in choline oxidase and it has been reported that replacement of Val464 with alanine in the enzyme results in a twofold decrease in the limiting rate constant for flavin reduction (k red ) and less than fivefold decrease in the equilibrium constant for formation of the enzymesubstrate complex (K d ) 52