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DHLA also regenerates ascorbate, which in turn reduces iron (Bonomi et al., Reparation of oxidized proteins Accumulation of oxidized proteins is thought to be the hallmark of the cells aging process (Berlett and Stadtman, 2004)

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Unfortunately, a clinical trial evaluating drugs targeting the IL-1 pathway, such as anakinra, for the treatment of AH, yielded negative results [135]