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Looking forward, three key research priorities emerge: (1) Mechanistic Elucidation: Future work must precisely define organelle-specific mechanisms, particularly the potential role of lipid droplet-mitochondria cross-talk in airway epithelial cells, and validate these pathways in human COPD samples

Spatial scatter plots of cell subsets and transcripts suggested that a robust IEC crypt base was associated with response to VDZ, while the abundance and activation of fibroblasts and MNPs were more linked to non-response prior to VDZ treatment (Fig

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10.1007/s11418-021-01534-w 108 LinF