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Furthermore, they could show that cells lacking both SLC25A39 as well as its paralogue SLC25A40 exhibit defects in the activity and stability of proteins containing ironsulfur clusters (ISCs)

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(PubMed) Xu R, Zhang S, Tao A, Chen G, Zhang M

Theoretical and reported concerns Off-target cell death: no compound is perfectly selective, so healthy cells with temporarily high FOXO4 could be affected in theory