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Among well-known senomorphic compounds, telomerase activators [120], caloric restriction diets [121] and mimetics [122], proteasome activators [123], autophagy activators [124], antioxidants [125], mTOR inhibitors [126], sirtuin activators [127], and anti-inflammatory agents targeting inflammaging /senoinflammation [128] can be mentioned

These two facts prove non-involvement of ROS in N2a death 40

However, the roles for many host metabolites including GSH in R