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Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

in the steady state, the transepithelial passage of small amounts of food-derived antigens and microorganisms participates in the induction of a homeostatic immune response dominated by immune tolerance to dietary antigens 1, 2 and the local production of secretory immunoglobulin A (SIgA), 3 preventing pathogenic and commensal microbes from entering internal compartments

Fu S, Zhu X, Huang F, Chen X