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Second, the results indicate that high levels of oxidative stress critically disrupt the glutathione redox potential and could cause apoptosis

Coyle JT, Tsai G, Bergeron R, Martina M, Berger-Sweeney J

In cardiovascular diseases, oxidative stress not only accelerates the oxidative depletion of BH 4 but also affects the expression and activity of DHFR (170)

Some hypotheses may explain the higher MDA values and the lower GPx activity, pointing to an oxidative stress in our patients: (a) older age (median 12.2 years) (b) a significant change in liver enzymes, malnutrition, and impaired lean mass variables not mentioned in the study by Squadrone et al