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We also acknowledge the grant support from NIH (AI103399, AR060366) for this work

the purification tag is an affinity tag and the method further comprises binding the complex to an affinity resin capable of binding the affinity tag

Additionally, melatonin suppresses other proinflammatory events, such as - amyloid toxicity, NO release, cyclooxygenase-2, and NLRP3 inflammasome activation, TLR4, and mTOR signaling, and cytokine release by senescence-associated secretory phenotype, among others