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Thus, evidences suggest that diamidines interfere in the kinetoplast function of trypanosomatids through a selective association to the unique AT-rich regions of kDNA minicircles, perhaps involving DNA-processing enzymes [146]

In this context, inhibiting TGF- can restore the function of CD8 + T cells, triggering cisplatin-induced ICD and thereby exerting an anti-tumor effect (Zhang Y

Pharmacokinetic studies showed that the modified M-NPs had higher blood retention and lower liver uptake, resulting in enhanced effectiveness for suppressing inflammatory cytokines in models of lipopolysaccharide-induced lung injury and endotoxemia