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Most of them arent actively patrolling your bloodstream

I have been very poorly since having spinal surgeries 12 years ago and have suffered intense pain all over my body,nerve pain, chronic fatigue, burning all over my body,(my feet feel as if they are being crushed) chest pain, heartburn, headaches, forgetfulness, depression, loss of smell and taste, I have been under the care of my GP, neurosurgeon and pain doctor for 15 years and have had all kind of tests done but they have all came back with nothing to explain my pain, two weeks ago I saw a different doctor who ordered different blood tests and it came back that my B12 was dangerously low (48) and my vitamin D is also very low, my doctor has ordered B12 injections (6 shots every other day) and then 3 monthly shots and also vitamin D supplements

As such, it has been studied extensively

Evidence is mixed but potentially helpful and safe