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Additionally, SNRIs such as duloxetine exert their analgesic effect by enhancing serotonin (5-HT) and norepinephrine (NE)-mediated descending inhibitory systems in the spinal cord (Obata, 2017)

223 Age-related hearing loss is accompanied by other age-related neurological changes and may result in social isolation, both of which could contribute to cognitive decline

Cascone T, Leung CH, Weissferdt A, Pataer A, Carter BW, Godoy MCB, Feldman H, William WN Jr, Xi Y, Basu S, Sun JJ, Yadav SS, Rojas Alvarez FR, Lee Y, Mishra AK, Chen L, Pradhan M, Guo H, Sinjab A, Zhou N, Negrao MV, Le X, Gay CM, Tsao AS, Byers LA, Altan M, Glisson BS, Fossella FV, Elamin YY, Blumenschein G Jr, Zhang J, Skoulidis F, Wu J, Mehran RJ, Rice DC, Walsh GL, Hofstetter WL, Rajaram R, Antonoff MB, Fujimoto J, Solis LM, Parra ER, Haymaker C, Wistuba II, Swisher SG , Vaporciyan AA, Lin HY, Wang J, Gibbons DL, Jack Lee J, Ajami NJ, Wargo JA, Allison JP, Sharma P, Kadara H, Heymach JV, Sepesi B

doi: 10.1186/s13041-019-0501-0 228 KennyEMFidanEYangQAnthonymuthuTSNewLAMeyerEAet al