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The figure also shows the net reaction: -ketoacid + CoASH (coenzyme A) + NAD + acyl-CoA + CO 2 + NADH + H +

doi: 10.1186/s12931-023-02634-9 74 RobertPNguyenPMCRichardAGrenierCChevrollierAMunierMet al

Similar to ferroptosis, Cu 2+ can generate a substantial amount of ROS via the Fenton reaction, leading to DNA damage, mitochondrial dysfunction, and lipid peroxidation, ultimately resulting in cell death [16, 103]