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J Pediatr (Rio J)

Testing this approach using modeling computational techniques, either PRKCA and PRKCG (but not PRKCB isoforms) are vulnerable to the substitution of divalent Ca++ by monovalent Li + via the C2 domain of cytosolic unbound-to-membrane PKC, suggesting that this could be a mechanism whereby Li + impedes PKC activation (Grauffel et al., 2021)