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At concentrations of 2% to 5%, topical spironolactone acts as a local anti-androgen without the systemic side effects (hyperkalemia, menstrual irregularity) associated with the oral form

[DOI] [PubMed] [Google Scholar] 363.Hider RC, Lerch K

A., Wolfe, R

Given TFAM's high abundance in mitochondrial nucleoids, this activity suggests it effectively competes with AP endonucleases in initiating damage processing