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Studies have shown that human adMSCs can differentiate into TM-like cells that not only resemble the morphology but also retain functional capabilities to regulate AH dynamics in mouse model in vivo (265)

As donor RGCs will need to extend axons through the optic nerve head to reach subcortical visual targets, it may be necessary to study axonal pathfinding and efferent synaptogenesis in species with a collagenous lamina cribrosa

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