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Description

DNA methylation in radiosensitivity DNA methylation exerts a substantial influence on the radioresistance of cancer cells

Bull., 1995, 18, 460

This "drug-like by design" philosophy has yielded a set of molecular guidelines: 9-11 amino acids, calculated lipophilicity (cLogP) 12.9, at least six N-alkylated amino acids, amide-based cyclization, and avoidance of charged residues