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Similarly, Ginkgolide B (GB), a key monomers of Ginkgo biloba extract, reduced NAFLD in mice fed a high-fat diet, and the WB results revealed the expression levels of ferroptosis-related proteins such as Nrf2, GPX4, HO-1, TFR1, and ferritin heavy chain-1 (FTH1) in vitro and in vivo

Carotenoids, used widely in the food industry, are divided into hydrocarbon carotenoids (carotenes) and oxygenated derivatives (xanthophylls) and serve as both dyes and secondary antioxidants, effectively scavenging reactive oxygen species due to their conjugated double bonds, thus helping prevent oxidative damage (94, 98)

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As LPS enhanced the phosphorylated Ser42 and Tyr198 in GSTP, we transfected GSTP mutants including GSTP-S42A, GSTP-S42D, GSTP-Y198F, GSTP-Y198D, and GSTP-S184D into RAW264.7 cells and then treated cells with LPS for 18 h