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ADCs not only extends the circulation time in vivo from minutes to hours, but also reduces uptake by cells through the endocytotic pathway, thereby enhancing passive delivery of drugs to diseased tissues [121]

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By facilitating Phase 2 liver detoxification, neutralizing the ROS that trigger mast cell degranulation, and protecting the autonomic nervous system from neuroinflammation, glutathione addresses the root metabolic dysfunctions driving these interconnected conditions

These findings imply that cardiac involvement may be one of the most common clinical features of FBXL4 deficiency (142)