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J Clin Endocrinol Metab (2009) 94:1797802

doi: 10.3109/10715762.2011.611509

Excessive iron accumulation in mitochondria causes oxidative stress, generating harmful free radicals that damage DNA, proteins, and lipids, ultimately impairing cardiac function ( / mice exhibited increased expression of mitoferrin 2 (Mfrn2), an iron transporter in the inner mitochondrial membrane

Additionally, ferrous oxidation-xylenol orange (FOX), thiobarbituric acid reactive substances (TBARS), and ROS concentrations in serum were determined ( Differences in systemic phospholipids were reported in another study involving dogs with idiopathic IBD and FRE ( While most studies have investigated the pathomechanisms of OS in chronic gastroenteritis, other studies have evaluated the role of antioxidants in acute enteropathy and in mitigating OS induced by surgery