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Shungus subsequent findings, which included finding low levels of the main antioxidant in the brain (glutathione) in ME/CFS patients, suggested that neuroinflammation and oxidative stress are the key culprits in ME/CFS and/or FM Shungu believes an antioxidant poor environment allows an infection to trigger a free radical explosion which shuts down the blood vessels causing a hypoxic low oxygen environment in the brain